C107 Carbenicillin disodium, Ultrapure/羧苄青霉素钠, Ultrapure

Carbenicillin disodium, Ultrapure/羧苄青霉素钠, Ultrapure
产品编号：C107 
产品规格：1g/5g

CAS Number	4800-94-6
Molecular Formula	C17H16N2Na2O6S
Molecular Weight	422.36 g/mol
Form	Powder
Appearance	White or off-white powder
Solubility	Water: Freely soluble
Source	Semi-synthetic
pH	6.0-7.5
Boiling Point	737.8 °C
Melting Point	>200 °C
Flash Point	400 °C
Storage Conditions	-20 °C

Description
Carbenicillin disodium, ultrapure is a member of the carboxypenicillin β-lactam antibiotic family.  TOKU-E offers two forms of carbenicillin: carbenicillin disodium (C004), and carbenicillin disodium, Ultrapure (C107). Both forms of carbenicillin are sparingly soluble in aqueous solution (0.45 mg/mL).
Mechanism
Carbenicillin interferes with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
Unlike most β-lactams, carbenicillin disodium is limited to primarily gram negative bacteria including Pseudomonas aeruginosa and common enteric species.
Microbiology Applications
Carbenicillin is often preferred over ampicillin in selection protocols because of its greater stability and longevity resulting in less contamination by unwanted satellite colonies. In addition, carbenicillin disodium, Ultrapure is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Pseudomonas aeruginosa 64 μg/mL - >512 μg/mL
Proteus mirabilis 1.56 μg/mL - >3.13 μg/mL
For a complete list of carbenicillin MIC values, click here.Plant Biology Applications
Carbenicillin has successfully been used in combination with Kanamycin in the transformation process of pear (cv. La France). Carbenicillin was succesfully selected as alternative bacterial growth regulator because of the low regeneration frequencies of this specific pear cultivar.
Mammalian Biology Applications