B014 Bacitracin, Ultrapure/杆菌肽, Ultrapure

Bacitracin, Ultrapure/杆菌肽, Ultrapure
产品编号：B014 
产品规格：10g

CAS Number	1405-87-4
Molecular Formula	C66H103N17O16S
Molecular Weight	1422.69 g/mol
Form	Powder
Appearance	White or yellow powder
Purity Level	Ultrapure, free of toxic and non-specific bacitracin fractions
Source	Bacillus Subtilis and B. Licheniformis.
Boiling Point	1750.1 °C
Melting Point	221-225 °C
Flash Point	1012.2 °C
Storage Conditions	2-8 °C, storage in an airtight container.

Description
Bacitracin is comprised of numerous antimicrobial peptide fractions. Notable fractions include A, A1, B, B1, B2, C, D, E, F, G, and X. Standard grade bacitracin (B002) is a mixture of these fractions and may be sufficient for routine microbiology research; however, toxic fractions may lead to false positive/negative results when used in IVD test kits. Ultrapure bacitracin has been selectively purified to remove toxins which help achieve more accurate results in IVD applications.
TOKU-E offers seven forms of bacitracin: bacitracin (B002), bacitracin ultrapure (B014), bacitracin A EvoPure? (B015), bacitracin B1 EvoPure? (B016), bacitracin B2 EvoPure? (B017), bacitracin F EvoPure? (B021), and bacitracin Xa EvoPure? (B018). EvoPure? products are purified single antibiotic fractions, most >99% pure. High purity EvoPure? bacitracin products can be used to analyze the specifc effects of individual bacitracin fractions.
Mechanism
Bacitracin prevents phosphorylation of bactoprenol; a transport protein which carries peptidoglycan components outside the cell membrane. Without the active phosphorylated bactoprenol, peptidoglycan synthesis cannot be complete and the cell lyses. Two mechanisms of bacitracin resistance are understood. One mechanism relies on a protein called a BcrABC transporter which pumps bacitracin out after it has entered the cell. An alternative mechanism is due to another protein called BacA which provides the active phosphorylated bactoprenol from a different synthetic pathway.
Spectrum
Bacitracin primarily targets the cell wall in members of the gram positive bacteria including Streptococcus pyogenes and Staphylococcus aureus.