A038 Aztreonam, solubilized/可溶性氨曲南

Aztreonam, solubilized/可溶性氨曲南
产品编号：A038 
产品规格：50mg/10g

CAS Number	78110-38-0
Molecular Formula	C13H17N5O8S2
Molecular Weight	435.43 g/mol
Form	Powder
Appearance	White powder
Purity Level	92.5-97.0%
Solubility	Freely soluble
Source	Synthetic
Water Content (Karl Fisher)	2.0%
Melting Point	227 °C
Storage Conditions	2-8 °C.

Description
Aztreonam is a β-lactam antibiotic known as a monobactam because of its unique structure which contains one rather than two rings fused together found in generic β-lactams such as ampicillin.  Because of its unique monocyclic structure, aztreonam is not typically inactivated by β-lactamases.
TOKU-E offers two forms of aztreonam: aztreonam (A017), and aztreonam solublized (A038).
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
Aztreonam targets primarily gram negative bacteria and shows little effect against gram positive and anaerobic bacteria.
Microbiology Applications
Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Pseudomonas aeruginosa ≤0.12 μg/mL － >16 μg/mL
Proteus mirabilis ≤0.12 μg/mL － >16 μg/mL
For a complete list of aztreonam MIC values, click here.Plant Biology Applications