A017 Aztreonam/氨曲南

Aztreonam/氨曲南
产品编号：A017 
产品规格：100mg

CAS Number	78110-38-0
Molecular Formula	C13H17N5O8S2
Molecular Weight	435.43 g/mol
Form	Powder
Appearance	White crystalline powder
Purity Level	≥98.0%
Solubility	DMF: Soluble DMSO: Soluble Ethanol: Slightly soluble Water: Insoluble
Source	Synthetic
Water Content (Karl Fisher)	2.0%
Melting Point	227 °C
Optical Rotation	-26o - -32o
Storage Conditions	2-8 °C.

Description
Aztreonam is a β-lactam antibiotic known as a monobactam because of its unique structure which contains one rather than two rings fused together found in generic β-lactams such as ampicillin.  Because of its unique monocyclic structure, aztreonam is not typically inactivated by β-lactamases.
TOKU-E offers two forms of aztreonam: aztreonam (A017), and aztreonam solublized (A038).
Mechanism
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum
Aztreonam targets primarily gram negative bacteria and shows little effect against gram positive and anaerobic bacteria.
Microbiology Applications
Aztreonam is commonly used in clinical in vitro microb