Asc-536 Vecuronium bromide/维库溴铵

Biological Description

Competitive nicotinic acetylcholine receptor (nAchrs) antagonist (IC₅₀ = 9.9 nM). Muscle relaxant. Inhibits neural response to hypoxia.

Useful References

Dilger et al (2007) Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists. Anesthesiology. 106:1186-95. abstract



Igarashi et al (2002) Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesth Analg. 94:117-22 abstract



Liu et al (2009) Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Mol Pharmacol. 75:166-73.abstract



 

Chemical Information

1-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide

• Desiccate at RT


• MW 637.74


• Soluble in DMSO


• C₃₄H₅₇BrN₂O₄


• 50700-72-6