Asc-529 Sibutramine hydrochloride/盐酸

Biological Description

Serotonin, noradrenalin(SNRI)and dopamine re-uptake inhibitor. Displays anorectic properties, induces increased energy expenditure and weight loss. Causes pressor and tachycardic effects.

Useful References

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J Pharmacol Exp Ther. 283:581-91. abstract



Frassetto et al (2010) Absence of sibutramine effect on spontaneous anxiety in rats. Arq Bras Endocrinol Metabol. 54:375-80. abstract



Woolard et al (2004) Acute cardiovascular effects of sibutramine in conscious rats. J Pharmacol Exp Ther. 308:1102-10. abstract



 

Chemical Information

1-(4-Chlorophenyl)-N,N-dimethyl-?-(2-methylpropyl)cyclobutanemethanamine hydrochloride

• Store at RT


• MW 316.31


• Soluble in water to 5 mM and in DMSO to 100 mM


• C₁₇H₂₆ClN.HCl


• 84485-00-7