Thapsigargin      Ca²⁺-ATPase inhibitor

Biological Description

A potent, cell-permeable Ca²⁺-ATPase inhibitor. Releases Ca²⁺ by inhibiting endoplasmic reticular Ca²⁺-ATPase (IC₅₀ = 4-13 nM). Both tumorogenic and apoptotic actions reported.

Useful References

Treiman et al (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol .19(4):131-5. abstract



Thastrup et al (1989) Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions. 27:17-23.



Inesi et al (1992) Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+ transport ATPases.Arch Biochem Biophys. 298:313-7. 

 

Chemical Information

(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6 ,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[ [(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutox y)azuleno[4,5-b]furan-7-yl octanoate

• Desiccate at -20°C


• MW 650.75


• Soluble to 100 mM in DMSO


• C₃₄H₅₀O₁₂


• 67526-95-8