Asc-354 Flufenamic acid/氟芬那酸

Biological Description

Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

Useful References

Peterson et al (1998) Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proc Natl Acad Sci U S A. 95:12956-60.abstract



Flower (1974). Drugs which inhibit prostaglandin biosynthesis. Pharmacol. Rev. 26: 33–67.



Hotta et al (2005) The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum. J Smooth Muscle Res. 41:207-20. abstract



Tu et al (2009) The anti-inflammatory agent flufenamic acid depresses store-operated channels by altering mitochondrial calcium homeostasis. Neuropharmacology. 56:1010-6. abstract

Chemical Information

2-(3-(Trifluoromethyl)phenylamino)benzoic acid

• Store at RT


• MW 281.23


• Soluble in DMSO to 100 mM in ethanol to 100 mM


• C₁₄H₁₀F₃NO₂


• 530-78-9