BIA-A1120 Aureothricin/金丝菌素

Aureothricin/金丝菌素
产品编号：BIA-A1120 
产品规格：0.5 mg/2.5 mg 
Aureothricin is an antibiotic first described by Umezawa and coworkers
in Japan in 1949. Resurgent interest in this class of
microbial metabolites was stimulated by the discovery of their
selective antitumor activity. Aureothricin is a more hydrophobic
analogue of thiolutin but has received only limited attention.
Members of this class, notably thiolutin, have been shown to
potent inhibitors of bacterial and yeast RNA polymerases and
inhibitors of mannan and glucan formation in fungi. Studies have
shown that thiolutin inhibits tumor cell-induced angiogenesis in
vivo.
CAS Number: 574-95-8
Molecular Formula: C9H10N2O2S2
Molecular Weight: 242.3
Source: from Streptomyces sp.
Purity: >98% by HPLC
金丝菌素（Aureothricin）
货号： BIA-A1120 包装规格: 0.5 mg, 2.5 mg
金丝菌素是由日本的umezawa与其同事于1949首次报导的抗生素。在发现它们具有选择性的活性后，重新激发了对这类微生物代谢产物的研究兴趣。金丝菌素是硫煌黄菌素的疏水性类似物，但是一直未受太多关注。这一大类中的成员，尤其是硫煌黄菌素，都是很有效的细菌跟酵母菌RNA聚合酶YZ剂，同时也是真菌体内甘露聚糖和葡聚糖形成的YZ剂。研究表明硫煌黄菌素可以YZ体内肿瘤细胞诱导的血管新生。
CAS 号: 574-95-8
分子式: C9H10N2O2S2
分子量: 242.3
来源: 来自于链霉菌属
纯度: >98% by HPLC