Berninamycin A/伯尔尼霉素A
产品编号:BIA-B1121
产品规格:1 mg/5 mg
Berninamycin A is an antibiotic discovered in 1976 isolated from a
Streptomyces. Berninamycin A is a macrocyclic "peptide"
comprising atypical amino acids linked to thiazole and oxazoles.
Chemically very complex, berninamycin A is an inducer of tipA, a
gene that controls the bacterial transcription regulators, TipAL and
TipAS, members of the MerR proteins that are central regulators in
multidrug resistence. Berninamycin is closely related to siomycin,
a recently discovered inhibitor of oncogenic transcription factor,
FoxM1.
CAS Number: 58798-97-3
Molecular Formula: C51H51N15O15S
Molecular Weight: 1146.1
Source: from Streptomyces sp.
Purity: >99% by HPLC
伯尔尼霉素 A(Berninamycin A)
货号: BIA-B1121 包装规格: 1 mg, 5 mg
伯尔尼霉素是一种在1976发现的抗生素,提取自一种链霉菌。伯尔尼霉素是一个大环肽链,是由连接到噻唑以及唑上的非常见氨基酸构成的。化学结构复杂,伯尔尼霉素A是tipA的诱导物之一,TipA 是一种控制细菌转录调控因子TipAL和TipAS的基因。TipAL和TipAS都是多药抗药性的ZX调控因子MerR蛋白家族的成员。伯尔尼霉素跟盐屋霉素紧密相关。盐屋霉素是近发现的针对致癌性转录因子FoxM1的YZ剂。
CAS号: 58798-97-3
分子式: C51H51N15O15S
分子式: 1146.1
来源: 来自于链霉菌属
纯度: >99% by HPLC