ERK Inhibitor

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产品名称：ERK Inhibitor

产品别名：Extracellular Regulated Kinase Inhibitor;

CAS号：1049738-54-6

英文别名：3-[(2-aminoethyl)-5-(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione hydrochloride

分子量：328.8

分子式：C₁₄H₁₆N₂O₃S • HCl

纯度：≥95%

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保存方法：Store at -20℃

描述：ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (K_D = 5 µM).¹ This prevents its interaction with protein substrates without inhibiting catalytic activity.¹ ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2.¹ Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC₅₀ = 15-20 µM), A549 lung carcinoma cells (IC₅₀ = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.¹

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