GSK 3787

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试剂描述：

产品名称：GSK 3787

产品别名：4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

CAS号：188591-46-0

英文别名：4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

分子量：392.78

分子式：C₁₅H₁₂ClF₃N₂O₃S

纯度：≥99%

外观：white

保存方法：Store at 4° C

描述：

GSK 3787 is a selective PPARβ (peroxisome proliferator-activated receptor β) antagonist which binds to Cys249 in the PPARβ binding pocket. PPARβ is essential in the catabolism of fatty acids. Studies indicate that GSK 3787 antagonizes the agonistic effects of GW 0742 . This inhibits upregulation of Angptl4 and Adrp mRNA expression in mice colon. In addition, GSK 3787 acts in a dual role as a weak agonist and antagonist towards PPARγ. These studies suggest that GSK 3787 also functions as an antagonist towards PPARβ which has similar functions to PPARδ.

应用：A potent and selective peroxisome proliferatior-activated recepter δ antagonist

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