PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

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产品名称：PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

产品别名：DHPI-3,4,5-P₃;Phosphatidylinositol-3,4,5-triphosphate C-6;PIP3C-16;

CAS号：799268-62-5

英文别名：PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

分子量：838.6

分子式：C₂₁H₅₄N₄O₂₂P₄ · 4NH₄

纯度：≥98%

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保存方法：Store at -20℃

描述：The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.^1,2 PtdIns-(3,4,5)-P₃, also known as PIP₃, is resistant to cleavage by PI-specific phospholipase C (PLC).³ Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP₃ can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains.⁴⁵ Protein binding to PIP₃ is important for cytoskeletal rearrangement and membrane trafficking.⁶ PtdIns-(3,4,5)-P₃ (1,2-dihexanoyl) is a synthetic analog of natural PIP₃ with C₆:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP₃, including higher solubility in aqueous media.

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