Palmitoyl 3-carbacyclic Phosphatidic Acid

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

试剂描述：

产品名称：Palmitoyl 3-carbacyclic Phosphatidic Acid

产品别名：3-ccPA 16:0;

CAS号：476310-22-2

英文别名：(2-hydroxy-2-oxo-1,2λ⁵-oxaphospholan-5-yl)methyl hexadecanoate

分子量：390.5

分子式：C₂₀H₃₉O₅P

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20℃

描述：Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate.^1,2 Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce LPA.³ Palmitoyl 3-ccPA is a cyclic LPA analog that contains the 16:0 fatty acid, palmitate, at the sn-1 position of the glycerol backbone.³ At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (81.9%) or LPA (98.9%) without affecting proliferation.³ 3-ccPA 16:0, at 0.1-25 μM, significantly inhibits autotaxin,^4,5 an enzyme that is important in cancer cell survival, growth, migration, invasion and metastasis.

应用：见爱必信官网

产品信息订购：

产品更多信息请进入爱必信网站咨询