Oleoyl Ethanolamide-d2

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产品名称：Oleoyl Ethanolamide-d2

产品别名：OEA-d₂;Oleic Acid Ethanolamide-d₂;

CAS号：1245477-09-1

英文别名：(9Z)-N-(2-Hydroxyethyl)(11,11-²H₂)-9-octadecenamide

分子量：327.5

分子式：C₂₀H₃₇D₂NO₂

纯度：≥99% deuterated forms (d₁-d₂)

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保存方法：Store at -20℃

描述：Oleoyl ethanolamide-d₂ (OEA-d₂) contains two deuterium atoms at the 11 position. It is intended for use as an internal standard for the quantification of OEA by GC- or LC-mass spectrometry. OEA is an analogue of the endocannabinoid arachidonoyl ethanolamide (AEA) found in brain tissue and in chocolate.¹ It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,² but its biosynthesis is reduced in the intestine of rats following food deprivation.³ OEA is an endogenous, potent agonist for peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC₅₀ value of 120 nM in a transactivation assay.⁴ Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.^3,4 These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.

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