nor-NOHA (acetate)

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产品名称：nor-NOHA (acetate)

产品别名：N^ω-hydroxy-nor-Arginine;

CAS号：1140844-63-8

英文别名：nor-NOHA (acetate)

分子量：296.3

分子式：C₅H₁₂N₄O₃ • 2C₂H₄O₂

纯度：≥97%

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保存方法：Store at -20℃

描述：L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with N^ω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a K_i value of 0.5 µM, which is 20-fold lower than the K_i of 10 µM observed for NOHA.¹ It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC₅₀ of 10-12 µM.² nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.^3,4

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