N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone

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产品名称：N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone

产品别名：3-oxo-C16:1-Δ¹¹cis-(L)-HSL;

CAS号：1269663-80-0

英文别名：N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone

分子量：351.5

分子式：C₂₀H₃₃NO₄

纯度：≥98%

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保存方法：Store at -20℃

描述：Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.¹ This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.² Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.³ AHLs vary in acyl group length (C₄-C₁₈), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.⁴ An unspecified positional and geometric isomer of 3-oxo-C16:1-(L)-HSL is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity.⁵

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