Luotonin A

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试剂描述：

产品名称：Luotonin A

产品别名：Luotonin A

CAS号：205989-12-4

英文别名：Luotonin A

分子量：285.3

分子式：C₁₈H₁₁N₃O

纯度：≥98%

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保存方法：Store at -20℃

描述：Luotonin A is an alkaloid originally isolated from a plant used in traditional Chinese medicine.¹ It inhibits the growth of mouse leukemia P388 cells (IC₅₀ = 1.8 μg/ml).¹ Luotonin A is structurally similar to the alkaloid camptothecin (Item No. 11694) and, like camptothecin, it binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC₅₀ = 5.07-12.6 μM).² Also like camptothecin, luotonin A forms non-covalent complexes with double-stranded DNA in the minor groove and this association can be followed by native fluorescence associated with the aromatic and heterocyclic ring structure.³ Luotonin A also selectively inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 (IC₅₀ = ~6 μM for each) in human liver microsomes.⁴

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