Indomethacin N-octyl amide

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产品名称：Indomethacin N-octyl amide

产品别名：2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-octyla cetamide

CAS号：282728-65-8

英文别名：2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-octyla cetamide

分子量：469

分子式：C₂₇H₃₃ClN₂O₃

纯度：≥98%

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保存方法：Store at -20℃

描述：Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.¹ Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ values of indomethacin N-octyl amide for the inhibition of ovine COX-1 and human recombinant COX-2 are 66 µM and 40 nM, respectively, making it 1,650 times more potent as an inhibitor of COX-2 than COX-1.² While indomethacin itself has an IC₅₀ of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 µM.

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