bpV(phen) (potassium hydrate)

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产品名称：bpV(phen) (potassium hydrate)

产品别名：Bisperoxovanadium(phen);Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V);

CAS号：171202-16-7

英文别名：bpV(phen) (potassium hydrate)

分子量：404.3

分子式：C₁₂H₈N₂O₅V • K+(H₂O)₃

纯度：≥99%

外观：见爱必信官网

保存方法：Store at -20℃

描述：bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC₅₀ = 38 nM).^1,2 It also inhibits the vascular endothelial PTP, PTP-β (IC₅₀ = 343 nM), and PTP-1β (IC₅₀ = 920 nM).^2,3 At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2.⁴ Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.^5,6,7

应用：见爱必信官网

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