3-bromo-5-phenyl Salicylic Acid

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产品名称：3-bromo-5-phenyl Salicylic Acid

产品别名：NSC 109116;

CAS号：4906-68-7

英文别名：3-bromo-2-hydroxy-5-phenylbenzoic acid

分子量：293.1

分子式：C₁₃H₉BrO₃

纯度：≥95%

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保存方法：Store at -20℃

描述：The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The ¹C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.¹ In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.^2,3,4,5 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (K_i = 4 nM) over AKR1C2 (K_i = 87 nM), AKR1C3 (K_i = 4.2 μM), and AKR1C4 (K_i = 18.2 μM).⁶ Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC₅₀ = 460 nM).⁶

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