17(R)-Resolvin D1 methyl ester

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产品名称：17(R)-Resolvin D1 methyl ester

产品别名：Aspirin-triggered-Resolvin D1 methyl ester;AT-RvD1 methyl ester;17-epi-Resolvin D1 methyl ester;17(R)-RvD1 methyl ester;

CAS号：937738-64-2

英文别名：Methyl (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)-7,8,17-trihydroxy-4,9,11 ,13,15,19-docosahexaenoate

分子量：390.5

分子式：C₂₃H₃₄O₅

纯度：≥95%

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保存方法：Store at -80℃

描述：17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 (Item No. 10012554) that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC₅₀ = ~30 nM).¹ 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.¹ In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. 17(R)-RvD1 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.

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