[Lys22]-beta-Amyloid (1-42), Italian Mutation

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试剂描述：

产品名称：[Lys22]-beta-Amyloid (1-42), Italian Mutation

产品别名：

CAS号：见爱必信官网

英文别名：

分子量：4513.2

分子式：见爱必信官网

纯度： ≥ 95%

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保存方法：-20°C

描述：

This is amino acids 1 to 42 fragment of the beta-amyloid peptide, with lysine substituted for glutamic acid at position 22 found in Italian families with Alzheimer's disease. The Italian mutation of beta -amyloid 1 to 42 (E22K) aggregates more rapidly and with more potent neurotoxicity than wild-type beta-amyloid (1-42). The formation of a salt bridge between Lys22 and Asp23 in the minor conformer might be a reason why E22K is more pathogenic than wild-type beta-amyloid (1-42).

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