染色体区域稳定蛋白/核输出蛋白1抗体,Anti-Exportin 1/CRM1抗体

抗体（antibody）指机体的免疫系统在抗原刺激下，由B淋巴细胞或记忆细胞增殖分化成的浆细胞所产生的、可与相应抗原发生特异性结合的免疫球蛋白。主要分布在血清中，也分布于组织液及外分泌液中。
染色体区域稳定蛋白/核输出蛋白1抗体想你所想  产品信息：
中文名称：染色体区域稳定蛋白/核输出蛋白1抗体   
英文名称：Anti-Exportin 1/CRM1
产品编号：byk-10151R
产品规格：0.1ml/0.2ml  
产品用途：科研实验
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染色体区域稳定蛋白/核输出蛋白1抗体想你所想  介绍：
CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli. 
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
染色体区域稳定蛋白/核输出蛋白1抗体想你所想 相关产品：
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