Ac-DEVD-AFC,Ac-Asp-Glu-Val-Asp-7-氨基-4-三氟甲基香豆素,201608-14-2

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试剂描述：

产品名称：Ac-DEVD-AFC

产品别名：Caspase-3 Substrate (Fluorogenic)

CAS号：201608-14-2

英文别名：Caspase-3 Substrate (Fluorogenic)

分子量：729.61

分子式：C₃₀H₃₄F₃N₅O₁₃

纯度：≥90%

外观：Powder

保存方法：Store at -20° C

描述：Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes' shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3.

应用：A fluorogenic substrate for caspase-3 and related cysteine proteases

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