Ubiquitin Isopeptidase Inhibitor II, F6,Ubiquitin Isopeptidase Inhibitor II, F6,157654-67-6(HClsalt)

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试剂描述：

产品名称：Ubiquitin Isopeptidase Inhibitor II, F6

产品别名：Ubiquitin Isopeptidase Inhibitor II, F6

CAS号：157654-67-6(HClsalt)

英文别名：Ubiquitin Isopeptidase Inhibitor II, F6

分子量：303.4

分子式：C₂₁H₂₁NO

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保存方法：Store at 4° C

描述：Ubiquitin Isopeptidase Inhibitor II, F6 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC₅₀ = 15.65 and 16.23 μM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway, selectively inhibiting USP (ubiquitin isopeptidase) activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6.

应用：A cell-permeable caspase activation and apoptosis inducer

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