17β-hydroxy Wortmannin,17.β.-hydroxy Wortmannin,58053-83-1

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产品名称：17β-hydroxy Wortmannin

产品别名：17.β.-hydroxy Wortmannin

CAS号：58053-83-1

英文别名：17.β.-hydroxy Wortmannin

分子量：430.4

分子式：C₂₃H₂₆O₈

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外观：见爱必信官网

保存方法：Store at -20° C

描述：17β-hydroxy Wortmannin is an analog of wortmannin . It irreversibly binds PI 3-kinase and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC₅₀ = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI 3-kinase and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC₅₀ = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin .

应用：An inhibitor of recombinant PI 3-kinase and mTOR

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