Linoleoyl glycine,Linoleoyl Glycine,2764-03-6

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试剂描述：

产品名称：Linoleoyl glycine

产品别名：Glycine linoleamide

CAS号：2764-03-6

英文别名：Glycine linoleamide

分子量：337.5

分子式：C₂₀H₃₅NO₃

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保存方法：Store at -20° C

描述：Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC₅₀ ~ 25 µM), which is less potent than that of arachidonyl glycine (IC₅₀ = 7 µM). The biological significance of linoleoyl glycine has not yet been determined.

应用：Which inhibits FAAH hydrolysis of AEA

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