Stat3 Inhibitor VIII, 5,15-DPP,5,15-二苯基-21H,23H-卟吩,22112-89-6

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试剂描述：

产品名称：Stat3 Inhibitor VIII, 5,15-DPP

产品别名：5,15-Diphenylporphyrin

CAS号：22112-89-6

英文别名：5,15-Diphenylporphyrin

分子量：462.54

分子式：C₃₂H₂₂N₄

纯度：>97%

外观：见爱必信官网

保存方法：Store at 4° C

描述：Stat3 Inhibitor VIII, 5,15-DPP is a cell-permeable porphyrin compound that binds Stat3 (STAT3, K_D = 880 nM by SPR) and prevents Stat3 SH2 domain-mediated ligand binding (IC₅₀ = 280 nM) and dimerization (~60% inhibition at 50 μM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC₅₀ = 10 μM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 μM. 5,15-DPP pre-treatment (50 μM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced Stat3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear Stat3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level.

应用：A cell permeable Stat3 binding porphyrin

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