NO-Indomethacin,4-nitrooxybutyl (2R)-2-acetamido-3-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]sulfanylpropanoate,301838-28-8

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产品名称：NO-Indomethacin

产品别名：4-nitrooxybutyl (2R)-2-acetamido-3-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]sulfanylpropanoate

CAS号：301838-28-8

英文别名：4-nitrooxybutyl (2R)-2-acetamido-3-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]sulfanylpropanoate

分子量：620.07

分子式：C₂₈H₃₀ClN₃O₉S

纯度：见爱必信官网

外观：Crystalline

保存方法：Store at -20° C

描述：NO-Indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This design combines the anti-inflammatory and Cox -1 and -2 inhibitory properties of indomethacin with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to indomethacin alone. NO-Indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC₅₀ of 82 μM, compared to >1,000 μM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.

应用：A Cox-1 and Cox-2 inhibitor and NO donor

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