Indirubin Derivative E804,Indirubin Derivative E804,854171-35-0

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试剂描述：

产品名称：Indirubin Derivative E804

产品别名：IDR E804

CAS号：854171-35-0

英文别名：IDR E804

分子量：365.39

分子式：C₂₀H₁₉N₃O₄

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

Indirubin Derivative E804 is a cell-permeable indirubin derivative (IDR) that inhibits the Src-Stat3 signaling pathway and displays anti-tumor properties. A potent, ATP-competitive inhibitor of the kinase activities of Src. Indirubin Derivative E804 decreases tyrosine phosphorylation levels of Src, JAK1, and Stat3 in MDA-MB-468 cells in a time- and dose-dependent manner. Selectively induces apoptosis in cells expressing high levels of active Stat3. Indirubin Derivative E804 is an inhibitor of Cdc2, Cdk2 and SRC.

应用：A cell-permeable inhibitor of Src-Stat3 signaling pathway

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