Gestrinone,孕三烯酮,16320-04-0

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产品名称：Gestrinone

产品别名：13-ethyl-17α-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

CAS号：16320-04-0

英文别名：13-ethyl-17α-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

分子量：308.4

分子式：C₂₁H₂₄O₂

纯度：≥99%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Gestrinone is a synthetic steroid occasionally used to treat endometriosis. The common disease endometriosis is characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis. It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin. Gestrinone binds to AR and PR with EC₅₀ values of approximately 20 and 30 nM, respectively. These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.

应用：A synthetic steroid that acts centrally on the hypothalamic-pituitary system

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