RO1138452,N-[4-[(4-propan-2-yloxyphenyl)methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine,221529-58-4

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产品名称：RO1138452

产品别名：4,​5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine

CAS号：221529-58-4

英文别名：4,​5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine

分子量：309.4

分子式：C₁₉H₂₃N₃O

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保存方法：Store at -20° C

描述：RO1138452 is one of the more potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, RO1138452 inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a K_i of about 1.5 nM. At levels between 2-20 mg/kg in rats, RO1138452 shows significant analgesic activity in standard antinociceptive assays.

应用：An IP receptor antagonist

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