11-deoxy Prostaglandin E1,11-脱氧前列腺素 e1,37786-00-8

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试剂描述：

产品名称：11-deoxy Prostaglandin E1

产品别名：11-deoxy PGE1; 9-oxo-15S-hydroxy-prost-13E-en-1-oic acid

CAS号：37786-00-8

英文别名：11-deoxy PGE1; 9-oxo-15S-hydroxy-prost-13E-en-1-oic acid

分子量：338.48

分子式：C₂₀H₃₄O₄

纯度：≥96%

外观：Crystalline

保存方法：Store at -20° C

描述：11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1 . Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC₅₀ of 0.25 μM. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The K_i values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.

应用：An agonist of EP2, EP3, and EP4

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