(±)12,13-DiHOME,(±)12,13-DiHOME,263399-35-5

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产品名称：(±)12,13-DiHOME

产品别名：12,13-dihydroxy-9Z-octadecenoic acid; Isoleukotoxin diol

CAS号：263399-35-5

英文别名：12,13-dihydroxy-9Z-octadecenoic acid; Isoleukotoxin diol

分子量：314.46

分子式：C₁₈H₃₄O₄

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保存方法：Store at -20° C

描述：(±)12,13-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12,13-EpOME. The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells.However, in renal cortical mitochondria, the conversion of the epoxide to 12,13-DiHOME appears to be part of the detoxification pathway that prevents mitochondrial dysfunction. This diol and the 9,10 isomer can be glucuronidated by human liver and intestinal microsomes as well as recombinant UGT2B7 through a hydroxyl group. High levels of LA-diol glucuronides have been found in the urine of humans with peroxisomal diseases. A mixture of the diols stimulates breast cancer cell proliferation in vitro and disrupts reproductive function in rats at relatively low concentrations.

应用：A diol resulting from the soluble epoxide hydrolase opening of (±)12,13-EpOME

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