N-(p-Aminophenethyl)spiperone,3-[2-(4-aminophenyl)ethyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one,93801-18-4

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产品名称：N-(p-Aminophenethyl)spiperone

产品别名：N-(p-Aminophenethyl)spiroperidol; 3-[2-(4-Aminophenyl)ethyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

CAS号：93801-18-4

英文别名：N-(p-Aminophenethyl)spiroperidol; 3-[2-(4-Aminophenyl)ethyl]-8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

分子量：514.63

分子式：C₃₁H₃₅FN₄O₂

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保存方法：Store at -20° C

描述：N-(p-Aminophenethyl)spiperone is an analogue of Spiperone . Spiperone is an 5-HT_2A serotonin and selective D₂-like dopamine receptor antagonist (K_i values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors respectively). Although the well known role of Spiperone in research studies indicates it acts as an antagonist of either 5-HT₂ or D₂ receptors, Spiperone has also been reported to act through a protein tyrosine kinase-coupled phospholipase C-dependent pathway. Spiperone was observed to act independent of either 5-HT₂ or D₂ receptors as reported In a study investigating the role of Spiperone and Ca²⁺ activated Cl^- channels (CaCC) in human cystic fibrosis (CF) airway epithelial cell monolayers in vitro.

应用：An analogue of Spiperone

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