Danofloxacin-d3 Mesylate,Danofloxacin-d3 Mesylate,119478-55-6(unlabeled)

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产品名称：Danofloxacin-d3 Mesylate

产品别名：Danofloxacin-d3 Mesylate

CAS号：119478-55-6(unlabeled)

英文别名：Danofloxacin-d3 Mesylate

分子量：456.5

分子式：C₂₀H₂₁D₃FN₃O₆S

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保存方法：Store at 4° C

描述：Danofloxacin-d3 Mesylate is a fluoroquinolone antibiotic which inhibits gram-negative bacteria. It is believed that Danofloxacin-d3 Mesylate inhibits Topo II (DNA gyrase) and triggers the activation of the SOS pathway along with temperate bacteriophages to inhibit bacterial growth. In addition, studies indicate that Danofloxacin-d3 Mesylate is a substrate for efflux-transporters such as P-gp, BCRP and MRP2, which are members of the ATP-Binding Cassette (ABC) superfamily. Ko 143 can inhibit the secretion of Danofloxacin-d3 Mesylate from BCRP but does not affect its absorption. Furthermore, MK-571 , an inhibitor of MRPs, can increase the absorption of Danofloxacin-d3 Mesylate on the apical membrane of Caco-2 cells. Also studies suggest that Danofloxacin-d3 Mesylate shows a stronger inhibiting effect in lysogenic E. coli bearing lambda prophages than in nonlysogenic E. coli.

应用：A labeled fluorinated quinolone antibacterial compound

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