Meclizine-d8 Dihydrochloride,Meclizine-d8 Dihydrochloride,1104-22-9(unlabeled)

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产品名称：Meclizine-d8 Dihydrochloride

产品别名：Meclizine-d8 Dihydrochloride

CAS号：1104-22-9(unlabeled)

英文别名：Meclizine-d8 Dihydrochloride

分子量：471.92

分子式：C₂₅H₂₁D₈Cl₃N₂

纯度：≥98%

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保存方法：Store at 4° C

描述：Meclizine-d8 Dihydrochloride is a labeled form of Meclizine Dihydrochloride , which functions as an antagonist at H1 receptors. It is known that Meclizine-d8 Dihydrochloride is similar in structure to Buclizine Dihydrochloride , cyclizine, and Hydroxyzine Dihydrochloride , but has a shorter half-life. In addition, Meclizine-d8 Dihydrochloride acts as an anticholinergic agent. Alternate studies suggest that Meclizine-d8 Dihydrochloride binds to the human pregnane X receptor (hPXR), which in turn recruits coactivator-1 to the receptor. Also Meclizine-d8 Dihydrochloride increases CYP3A4 gene expression, while decreasing the activity of testosterone 6β-hydroxylation which is catalyzed by the enzyme CYP3A.

应用：A labeled form of Meclizine Dihydrochloride

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