13,14-dihydro-15-keto Prostaglandin E2-d4,13,14-dihydro-15-keto Prostaglandin E2-d4,363-23-5(unlabeled)

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产品名称：13,14-dihydro-15-keto Prostaglandin E2-d4

产品别名：13,14-dihydro-15-keto Prostaglandin E2-d4

CAS号：363-23-5(unlabeled)

英文别名：13,14-dihydro-15-keto Prostaglandin E2-d4

分子量：356.5

分子式：C₂₀H₂₈D₄O₅

纯度：见爱必信官网

外观：A solution in methyl acetate

保存方法：Store at -20° C

描述：13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dihydro-15-keto PGE2-d4) is an isotopically labeled metabolite of PGE2 , with deuterium atoms substituted at the 3 and 4 methylene carbons. 13,14-dihydro-15-keto PGE2 is biosynthesized by the enzymes 15-hydroxy PGDH and 15-oxo-PG δ13-reductase. This compound accumulates to detectable levels, and then undergoes further metabolism and chemical decomposition, giving it a relatively short half-life (~ 9 minutes), yet is longer than PGE2 (~ 2 minutes), allowing this compound to build up to appreciable levels during PGE2 expression. Receptor binding studies indicate that although metabolites of prostaglandins typically bind to EP receptors with lower affinity, they might still play an important role in these biochemical pathways.

应用：An isotopically labeled metabolite of PGE2 with longer half-life

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