DPO-1,[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene,43077-30-1

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产品名称：DPO-1

产品别名：Diphenyl phosphine oxide-1; [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methyle­thyl)cyclohexyl]diphenylphosphine oxide

CAS号：43077-30-1

英文别名：Diphenyl phosphine oxide-1; [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methyle­thyl)cyclohexyl]diphenylphosphine oxide

分子量：340.44

分子式：C₂₂H₂₉OP

纯度：≥99%

外观：Powder

保存方法：Store at 4° C

描述：DPO-1 is a blocker of Kv1.5 channel and IK_ur ultrarapid delayed rectifier potassium current. (IC₅₀ = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IK_ur over I_to (8-fold), IK₁, IK_r and IK_s (20-fold) in native myocytes and selectivity for rat recombinanant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

应用：A blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current

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