Diminutol,(2R)-2-[[6-(3-aminophenyl)sulfanyl-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol,361431-33-6

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产品名称：Diminutol

产品别名：NG72

CAS号：361431-33-6

英文别名：NG72

分子量：386.51

分子式：C₁₉H₂₆N₆OS

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Diminutol is a cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Diminutol has been shown to interact with the NADP binding site and directly affect tubulin polymerization. Diminutol does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Diminutol has been shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50μM.

应用：A cell-permeable purine analog that inhibits NQ01 and blocks mitotic spindle assembly

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