Methotrexate Dimethyl Ester,Methotrexate Dimethyl Ester,34378-65-9

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产品名称：Methotrexate Dimethyl Ester

产品别名：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Dimethyl Ester; Dimethyl Methotrexate

CAS号：34378-65-9

英文别名：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Dimethyl Ester; Dimethyl Methotrexate

分子量：482.49

分子式：C₂₂H₂₆N₈O₅

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：Methotrexate Dimethyl Ester is the esterified form of Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate Dimethyl Ester can act as a folic acid antagonist. Methotrexate competitively and irreversibly inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate Dimethyl Ester can suppress T cell activation and adhesion molecule expression through IL-1 suppression.

应用：The esterified form of Methotrexate

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