Lck Inhibitor,7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3?d]pyrimidin-4-ylamine,213743-31-8

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试剂描述：

产品名称：Lck Inhibitor

产品别名：7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine

CAS号：213743-31-8

英文别名：7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine

分子量：370.45

分子式：C₂₃H₂₂N₄O

纯度：≥95%

外观：见爱必信官网

保存方法：Store at 4° C

描述：Lck Inhibitor is a cell-permeable pyrrolopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of Lck (IC₅₀ at 5 μM ATP = < 1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck_64-509 Y₃₉4, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC₅₀ at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC₅₀ = 3.2 μM, > 33 μM, > 50 μM and > 50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50 < 1-40 nM in Jurkat T cells).

应用：A cell-permeable ATP-competitive inhibitor of Lck

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