Indirubin-3'-monoxime,靛玉红-3’-单肟,160807-49-8

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产品名称：Indirubin-3'-monoxime

产品别名：Indirubin-3’-oxime 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

CAS号：160807-49-8

英文别名：Indirubin-3’-oxime 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

分子量：277.3

分子式：C₁₆H₁₁N₃O₂

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC₅₀=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC₅₀=180 nM) and CDK5 (IC₅₀=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.

应用：A potent inhibitor of GSK-3β, Cdk1, and Cdk5

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