cis-ACCP,cis-ACCP,777075-44-2

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试剂描述：

产品名称：cis-ACCP

产品别名：cis-ACCP

CAS号：777075-44-2

英文别名：cis-ACCP

分子量：222.2

分子式：C₇H₁₅N₂O₄P

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：cis-ACCP is a reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC₅₀ = 4 and 20 μM, respectively). At 100 μM, cis-ACCP prevents 90% of tumor cell invasion across matrigel-coated membranes in vitro. Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue repair and remodeling by degrading extracellular matrix proteins, thus enabling cell migration. Overexpression of MMPs are linked to diseases such as arthritis, cancer, osteoporosis and arteriosclerosis.

应用：A reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9

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