CCR2 Antagonist,2-(3-异丙基脲基)-N-(2-((1R,2S)-2-(4-(甲基硫基)苯甲酰胺基)环己基氨基)-2-氧代乙基)-5-(三氟甲基)苯甲酰胺,445479-97-0

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产品名称：CCR2 Antagonist

产品别名：CC Chemokine Receptor 2 Antagonist

CAS号：445479-97-0

英文别名：CC Chemokine Receptor 2 Antagonist

分子量：593.7

分子式：C₂₈H₃₄F₃N₅O₄S

纯度：≥97%

外观：见爱必信官网

保存方法：Store at 4° C

描述：CCR2 Antagonist is a cell-permeable cis-diamidocyclohexyl urea compound with high affinity binding to CKR-2B (chemokine receptor 2; CCR2), also designated CD192. CKR-2B is a G protein-coupled receptor with a unique conserved glutamic acid residue in transmembrane 7, Glu291. Research shows that this conserved residue is a critical site for small molecule antagonist binding. MCP-1 (chemokine ligand 2; CCL2) is a specific chemokine for the CKR-2B receptor and is responsible for recruiting monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. CCR2 Antagonist displays high affinity binding for CKR-2B ( IC₅₀ = 5.1 nM) and potent functional antagonism (calcium flux IC₅₀ = 18 nM and chemotaxis IC₅₀ = 1 nM). Although Glu291 is a key receptor residue for CKR-2B, CCR2 Antagonist studies show that this inhibitor is not reliant upon Glu291 for its affinity binding, rather a nearby site. CCR2 Antagonist exhibits preferential binding for CKR-2B over CKR-3 (CCR3).

应用：A highly potent CKR-2B (CCR2) receptor antagonist

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