Cdk2 Inhibitor IV, NU6140,4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide,444723-13-1

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产品名称：Cdk2 Inhibitor IV, NU6140

产品别名：4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide; Cdk2 Inhibitor IV

CAS号：444723-13-1

英文别名：4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide; Cdk2 Inhibitor IV

分子量：422.52

分子式：C₂₃H₃₀N₆O₂

纯度：≥95%

外观：见爱必信官网

保存方法：Store at 4° C

描述：Cdk2 Inhibitor IV, NU6140 is a highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC₅₀ = 6.6 μM, 0.41 μM, 5.5 μM, 15 μM and 3.9 μM for Cdc2 (Cdk1)/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Cdk2 Inhibitor IV, NU6140 has been shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulating survivin. Cdk2 Inhibitor IV, NU6140 has also been shown to synergistically potentiate paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.

应用：A highly cell-permeable purine compound that acts a ATP-competitive inhibitor of Cdks

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