8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt,8-氯腺苷-3,5-环状磷酸钠盐,41941-56-4

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产品名称：8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt

产品别名：8-氯腺苷-3,5-环状磷酸钠盐

CAS号：41941-56-4

英文别名：8-CHLORO-CAMP

分子量：385.6

分子式：C₁₀H₁₀ClN₅O₆P Na

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt is a site-selective cAMP analog that inhibits various cancer cell lines such as HT29 colorectal cells and ZR-75-1 breast carcinoma, which is due to selective activation of PKA (protein kinase A) isoenzymes. Studies show that 8-Chloroadenosine 3',5'-Cyclic Monophosphate down-regulates the RI α subunit and up-regulates the RII β subunit of cAMP-dependent protein kinases leading to type II holoenzyme-dependent growth inhibition of caner cells such as HL-60. In addition, it is suggested that 8-Chloroadenosine 3',5'-Cyclic Monophosphate can possibly stimulate the antitumor effect of taxanes at micromolar concentrations. Further studies show that mdr-1 mRNA expression is reduced greatly in the presence of 8-Chloroadenosine 3',5'-Cyclic Monophosphate.

应用：A cAMP analog with high selectivity for PKA I

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