6-Methoxy-2-Naphthylacetic acid,6-甲基萘乙酸,23981-47-7

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产品名称：6-Methoxy-2-Naphthylacetic acid

产品别名：6-MNAA; 6-MNA

CAS号：23981-47-7

英文别名：6-MNAA; 6-MNA

分子量：216.2

分子式：C₁₃H₁₂O₃

纯度：≥99%

外观：见爱必信官网

保存方法：Store at room temperature

描述：6-Methoxy-2-Naphthylacetic acid is a competitive inhibitor of Cox (cyclooxygenase). 6-Methoxy-2-Naphthylacetic acid is selective for Cox-2 (IC₅₀ = 15-55 μM) over Cox-1 (IC₅₀ = 200-280 μM). 6-Methoxy-2-Naphthylacetic acid is a metabolite of Nabumetone with potential analgesic and anti-inflammatory effects. 6-Methoxy-2-Naphthylacetic acid has been shown to alter the pharmacokinetics and brain accumulation of IMP in monkeys. 6-Methoxy-2-Naphthylacetic acid was able to decrease reactive oxygen species creation in polymorphonuclear leukocytes. Evidence points out that 6-Methoxy-2-Naphthylacetic acid is phototoxic in vitro.

应用：A competitive and selective inhibitor of Cox-2

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