5-IODO-A-85380 dihydrochloride hydrate,(S)-5-碘-3-[(2-氮杂啶)-甲氧基]吡啶,213764-92-2

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产品名称：5-IODO-A-85380 dihydrochloride hydrate

产品别名：(S)-5-碘-3-[(2-氮杂啶)-甲氧基]吡啶

CAS号：213764-92-2

英文别名：5-Iodo-A-85380 dihydrochloride,3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridinedihydrochloride

分子量：363.03

分子式：C₉H₁₁IN₂O•2HCl

纯度：≥98%

外观：Powder

保存方法：Desiccate at -20° C

描述：5-IODO-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for AChR α4β2 and AChR α6β2. It activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC₅₀ values are 12.7 and ~35 nM respectively). 5-IODO-A-85380 dihydrochloride is ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle AChR, respectively.

应用：A subtype-selective agonist for AChR

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